Syphilitic Aneurysm --------------------------- Syphilitic Aneurysms arise during tertiary syphilis due to chronic inflammation in the tunica adventitia of large elastic arteries, particularly the aorta. The inflammatory response to the spirochetes causes an obliterative endarteritis of the vaso vasorum, leading to a loss of blood supply to the elastic tunica media. Ischemia of the tunica media, combined with further syphilitic invasion into the tunica media itself, results in medial destruction
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