Cotrimoxazole in biology
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Cotrimoxazole in biology
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Classify Rx on Instagram: "📝 Cotrimoxazole (TMP-SMX) for Pneumocystis jirovecii Pneumonia (PCP) 📍 Fungus that behaves differently - P. jirovecii is classified as a fungus but lacks ergosterol in its cell membrane (unlike other fungi) - antifungals targeting ergosterol (azoles, amphotericin B) are therefore ineffective 📍 Cotrimoxazole targets folate synthesis - TMP-SMX blocks dihydrofolate reductase and dihydropteroate synthase in P. jirovecii - disrupts DNA synthesis, making it highly effecti
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