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There is an enzyme most people with throat symptoms have never heard of, and it is the reason acid suppression alone so often misses silent reflux. Pepsin is a stomach enzyme built to digest protein. It rides up with refluxate, acidic or not, and embeds into the tissue of the throat and esophagus. At the pH of a healthy throat it sits inactive, but it stays stable there for at least 24 hours and switches back on the next time the pH drops, keeping about 79% of its activity. Johnston et al. 2007,
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