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Answer: C (Sickle cell disease) Here is the explanation: Dactylitis, or painful hand-foot syndrome, is often one of the earliest signs of sickle cell disease in young children. It occurs due to vaso-occlusion, where sickled red blood cells block small blood vessels, leading to localised ischaemia and inflammation. This results in painful swelling, particularly in the small bones of the hands and feet. A) Iron deficiency anaemia is unlikely, as it typically presents with fatigue and pallor rather
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