Preventing PJI: The Window of Opportunity - Dr. Johannes F. Plate emphasizes a critical truth in our latest Master Class: the first few hours after surgery represent the greatest window of opportunity to prevent periprosthetic joint infections, before planktonic bacteria form mature biofilms that resist antibiotics and evade the immune system. He explores NanoCept, an innovative antibacterial implant coating with covalently bonded molecules that kill bacteria on contact, achieving near 100% redu
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Acute PJI: The Perioperative Window - Dr. Johannes F. Plate reveals a sobering reality in our latest Master Class: acute periprosthetic joint infections represent 47-70% of all PJIs, with the majority occurring within the first three months post-surgery during that critical perioperative window. Despite advances like laminar airflow and sterile protocols, even the cleanest ORs harbor 10-300 bacterial colonies, while surgical personnel shed up to a million skin squames per hour—each potentially c
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