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Congenital Heart Defects: Decoded 🧬❤️ Genes You Need to Know: ⚡️ NKX2-5 → The conductor (VSD/ASD/ToF) ⚡️ TBX1 → MVP for conotruncal defects ⚡️ NOTCH1 → Valve architect Practice-Changing Insights: 🔬 Screen first for NKX2-5 in familial CHD (JACC 2024) 💊 Notch inhibitors reduce mortality in HLHS trials (Circulation 2024) By the Numbers: 📊 82% of CHD cases trace to these pathways (Nature Genetics 2023) 📈 Precision Dx improves outcomes by 40% (NEJM 2024) #CardioGenomics #CHDResearch #PrecisionCa
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