Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.

Jun 9, 2020 · The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells.

CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production.

Jul 4, 2025 · Exogenous CD2 supplementation enhances the ability of CAR-T cells to form high-quality synapses, reduces T-cell exhaustion, and increases sustained antitumor efficacy.

Nov 13, 2025 · CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Extracutaneous Mastocytoma. Among its related …

Jan 6, 2026 · Patients with T-cell lymphomas and leukemias have overall poor outcomes due to the lack of targeted and effective treatments, particularly in the relapsed and refractory …

Jul 25, 2025 · CD2 is a protein found on the surface of certain immune cells, acting as a marker. These specialized proteins play a part in how cells interact and respond within the immune …

Feb 9, 2025 · CD2 is a cell surface glycoprotein expressed on T cells and natural killer (NK) cells, playing a crucial role in cell adhesion, immune synapse formation, and signal transduction.

Explore the CD2 gene, its function, expression, and role in immune responses. Learn about CD2 signaling, deficiency, and its potential implications in various diseases.

CD2 is a type I single-pass transmembrane glycoprotein of around 50–58 kDa which is a member of the immunoglobulin superfamily. The protein structure of CD2 underlies many of its …