The median time to reach a diagnosis of ATTR-CM from the time of heart failure diagnosis was 490 days (1.3 years). There are clinically important delays between the incidence of heart failure and the ...

More than one-third of the elevated serum proteins reflected muscle fiber damage and leakage into the bloodstream. A large, reproducible set of blood-based protein biomarkers can reliably distinguish ...

Patients with ATTR-CM who experienced outpatient worsening heart failure had a 2.5-fold increased risk of mortality compared with those who did not. Outpatient worsening heart failure is an ...

Almost all (97%) of the patients with positive planar imaging and positive single-photon emission computed tomography findings were diagnosed with ATTR-CM. Single-photon emission computed tomography ...

Biochemical response rates were sustained through week 182 in patients with PBC treated with elafibranor, and the proportion of patients with normal alkaline phosphatase levels remained consistent.

Histological analysis showed myocyte hypertrophy as well as interstitial and endocardial fibrosis. Researchers from the US presented the case of a patient with severe left ventricular hypertrophy with ...

The researchers found that Asian ethnicity was independently associated with younger age, greater social deprivation, and noncompliance with treatment. People from India, Pakistan, and Bangladesh, ...

In terms of glucocorticoid remission, the rituximab cohort achieved better results (52.1%) compared with the intravenous cyclophosphamide group (30.9%). Rituximab was found to be significantly ...

Emerging therapies such as bezuclastinib and elenestinib show promise in improving disease control with potentially fewer toxicities. Other novel strategies, such as immune-based therapies, are under ...

Therapeutic drug monitoring-based maintenance showed continued efficacy with a reduced need for infusions and 16.2% lower costs. Therapeutic drug monitoring (TDM) may be useful for patients with ...

The results of the current meta-analysis reinforce the safety and efficacy of marstacimab in reducing annualized bleeding rates among patients with severe hemophilia A and B. Among patients with ...

The Pettersson score remains a valuable tool in assessing joint damage in children with hemophilia. In a letter to the editor of the Indian Journal of Radiology and Imaging, Yadav and colleagues ...