Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

San Francisco 49ers running back Christian McCaffrey reflected on his 2024 NFL season that fell short of expectations with a ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason out.

BUFFALO, N.Y. (WKBW) — For the second time this season and the 14th time in his career, Buffalo Bills quarterback Josh Allen ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

An Arctic cold front will bring intense snow squalls, strong winds and heavy lake-effect snow to parts of the Northeast, ...