Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly ...

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

It's the Bills vs the 49ers in Week 13 of the 2024 NFL season. Here's how to watch, including time, channel, TV schedule and ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...