Being without Brock Purdy against the Green Bay Packers stung the San Francisco 49ers. It essentially chalked up the game as ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

San Francisco 49ers head coach Kyle Shanahan told reporters that quarterback Brock Purdy did some light throwing without any ...

San Francisco 49ers quarterback Brock Purdy is the latest star to receive a positive "PupTalk" from the characters of Nickelodeon's PAW Patrol.

The San Francisco 49ers are facing an uphill battle in their quest to earn a playoff spot after suffering their second ...

The 49ers keep losing key players to injuries. The latest one who could miss time is rookie right guard Dominick Puni. He ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

If we've learned anything about the San Francisco 49ers brain trust this season, we can't take what they say at face value. After all, we saw 49ers star running ...

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...