The San Francisco 49ers looked out of their element as the Buffalo Bills cruised to an easy 35-10 win on Sunday Night ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday Night Football, rumbling past them 35-10. Not only did this win ...

Larry, Wes and Spoff share their three things ahead of the Green Bay Packers' road matchup with the Detroit Lions.

In an otherwise boring game against San Francisco -- the result of the game was never in question -- Bills quarterback Josh ...

Well, that wasn't fun. The San Francisco 49ers looked like they were cooking early in the game, but eventually, the Buffalo ...

ESPN's "Sunday NFL Countdown" briefly took a more serious turn this week when Randy Moss disclosed an ongoing medical ...

Los San Francisco 49ers visitaron el Highmark Stadium para enfrentar a los Buffalo Bills. San Francisco sufrió una derrota 35 ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Bills quarterback Josh Allen and head coach Sean McDermott celebrated by making snow angels after Buffalo clinched its fifth ...

The San Francisco 49ers may soon lose one of their best offensive players to the Minnesota Vikings in free agency.

Buffalo Bills running back James Cook looked phenomenal in his team's Week 13 win over the San Francisco 49ers, and his ...