San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.

The San Francisco 49ers looked out of their element as the Buffalo Bills cruised to an easy 35-10 win on Sunday Night ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday Night Football, rumbling past them 35-10. Not only did this win ...

The Houston Texans defeated the Jacksonville Jaguars, 23-20, on Sunday afternoon, but the game itself was far from the top ...

Larry, Wes and Spoff share their three things ahead of the Green Bay Packers' road matchup with the Detroit Lions.

In an otherwise boring game against San Francisco -- the result of the game was never in question -- Bills quarterback Josh ...

Well, that wasn't fun. The San Francisco 49ers looked like they were cooking early in the game, but eventually, the Buffalo ...

ESPN's "Sunday NFL Countdown" briefly took a more serious turn this week when Randy Moss disclosed an ongoing medical ...

Los San Francisco 49ers visitaron el Highmark Stadium para enfrentar a los Buffalo Bills. San Francisco sufrió una derrota 35 ...

The snow has been falling heavy and fast across the Great Lakes region — but that did not stop the Buffalo Bills football game Sunday night. They dominated the visiting San Francisco 49ers in a ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...