Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses

Immunotherapy, which uses a patient's immune system to treat disease, has increased survival for some adults and children ...
Hosted on MSN

Scientists track real-time signaling in T cell activation to show how the immune system defends against threats

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...
Newswise

Targeting ZMYND8 improves T-cell function and may boost immunotherapy

Explore new St. Jude research finding how removing the immune response “brake” gene ZMYND8 led to better control of solid tumors and chronic viral infections.
GEN

Next-Gen CAR T Cells Destroy Cancer Cells with Fewer Toxic Effects in Mice

Researchers at the Keck School of Medicine of University of Southern California (USC) have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response ...
BIOENGINEER

Rewired 2B4 Signal Gives CAR-NK Cells a Lasting Anti-Cancer Edge

Natural killer cells have long been viewed as the immune system’s blunt but dependable first responders, capable of destroying tumor cells without the elaborate priming that T cells require. In r ...
Phys.org

AI model decodes cell signaling fingerprints across diverse cell types

The fate of each cell—what type of specialized cell it will become—depends on which genes are turned on or off in the cell. These patterns of gene activity shape the cell's structure and function, ...