Spiroketals are privileged substructures found in numerous natural products. Even relatively simple spiroketals exhibit a range of biological activities. In more complex structures, spiroketals often ...

Garsubellin A, which was originally isolated from the wood of Garcia subelliptica by Fukuyama et al. 1 has been identified as a potent inducer of choline acetyltransferase, which is a key enzyme for ...

Cross-coupling reactions typically rely on the use of transition metal catalysis. However, although achieving this process using metal-free organocatalysts is highly challenging, it could offer unique ...

A quote from Rudolph Buchheim, an experimental pharmacologist who lived from 1820 to 1879, summarizes the nature and importance of studies in drug metabolism, including the pharmacokinetics and ...