DNA polymerase epsilon (PolE) in an enzyme essential for DNA replication. Deficiencies and mutations in PolE cause severe developmental abnormalities and cancers. Paradoxically, the catalytic domain ...
Viral replication relies fundamentally on specialised DNA polymerases that orchestrate genome synthesis, fidelity control and interaction with viral and host factors. These enzymes exhibit remarkable ...
This is part twenty of a series, “How SARS-CoV-2 Delays, Evades, and Suppresses the Immune System.” SARS-CoV-2 proteins are like Swiss army knives. They have many functions. Here we describe one of ...
Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...
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