Understanding how proteins are regulated remains a fundamental challenge in molecular biology. Our findings demonstrate how a flexible, disordered protein segment — an intrinsically disordered region ...

While the regulation of protein function theoretically encompasses alterations in both structural conformation and dynamic properties, the latter aspect, specifically conformational entropy, remains ...

In a study published in Nature Communications, researchers at the University of Wisconsin–Madison introduced a deep learning method capable of automatically identifying transition states in protein ...

Northwestern Medicine scientists have developed a new experimental method to analyze conformational fluctuations in protein domains on a uniquely large scale, which may improve data-driven modeling, ...

Recently, the research team of Prof. WANG Qian from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) and Prof. BAI Fang from ShanghaiTech University ...

For many people, "protein" is the key element of a food order. However, beyond the preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose ...

In Greek mythology, Proteus, son of Poseidon and prophetic shepherd of sea-beasts, could foretell the future. The elusive sea god was difficult to capture as he assumed many forms—a lion, a serpent, ...

The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...

A newly developed generative AI model is helping researchers explore protein dynamics with increased speed. The deep learning system, called BioEmu, predicts the full range of conformations a protein ...

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...