Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

Biological muscles act as flexible actuators, generating force naturally and with an impressive range of motion. Unsurprisingly, scientists and engineers have been striving to build artificial muscles ...

With the intensification of global population aging, muscle atrophy, characterized by the loss of muscle mass and function, has become an important health issue affecting the elderly. Researchers have ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Muscle atrophy is a primary characteristic of both sarcopenia and cachexia, significantly impacting physical function and quality of life. This figure illustrates the multifaceted causes of muscle ...

Findings show that impaired autophagy leads to muscle degeneration, inflammation, and mitochondrial defects, while ...

Following the US Food and Drug Administration (FDA) announcement on the phasing out of animal testing, the drug development industry has welcomed a wave of new approach methodologies (NAMs). However, ...