GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Cells are defined by the genes they express. In human cells, there are thousands of different protein coding genes, and the expression of those genes is carefully orchestrated and controlled by a ...

Gene editing is now reaching the mainstream, ushering in a new era of genetic manipulation. Traditionally, inserting or deleting entire genes, regulating their expression, and altering specific ...

This effectively silences the genes, like deleting an email draft before its writer can press send. "We found that genetic variations that increase unproductive splicing often decreased gene ...

Oregon Health & Science University has a leading role in a new database designed to track the normal expression of genes in organs and tissues from prenatal development through adulthood. Researchers ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Antisense oligonucleotides (ASOs), used to treat genetic diseases, can affect how cells repair damage to their DNA. This is ...

Scientists have found that a special component in some people's blood provides them with natural protection against malaria.

A new study suggests that the Agouti gene in the brains of male African striped mice can act as a molecular "switch," making ...