New Study Reveals How the C/G Fusion Hijacks DNA Methylation and Chromatin Architecture to Drive Aggressive AMKL Pediatric ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells. What determines these differences? It all comes down to gene ...

Join Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, to learn more about how the Hodges Lab is utilizing the 6-base genome to investigate the dynamics of enhancer DNA ...

Scientists map the true nature of the genome with its loops and folds in four dimensions across time and space.

Type-2 helper T (Th2) cells play intricate roles in the inflammatory response underlying asthma. Elevated levels of the protein GATA3 stimulate the maturation of these cells. Consequently, gene ...

Multiple myeloma (MM) affects over 5,500 people annually in the UK, with a 5-year survival rate below 50% in advanced stages. Resistance to therapies is driven by transcriptional addiction, where ...

In Pick’s disease, as in Alzheimer’s disease and frontotemporal dementia, tangled tau spells trouble. In this subtype of FTD, abnormal clumps of three-repeat tau called Pick bodies abound in neurons.

In part 2 of this webinar, Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilizing the 6-base genome to ...