The class of drugs known as DNA Damage Response inhibitors, which work by blocking cancer cells’ ability to repair their own damaged DNA, is expanding rapidly beyond its original anchor, the PARP ...

Pancreatic cancer is one of the deadliest cancers and the third-leading cause of cancer-related death in the United States.

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 ...

Researchers from the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, together with collaborators from ETH Zürich, the Malopolska Center of Biotechnology and the ...

Hyperreactivity of the gene responsible for DNA repair may indicate a hidden vulnerability of oncological diseases and help ...

Add Yahoo as a preferred source to see more of our stories on Google. Double-strand breaks in DNA can be deadly. Victor Golmer/iStock via Getty Images Plus Your DNA is continually damaged by sources ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...

Cancer cell death following genotoxic therapy is often attributed to excessive or unrepaired genome damage. However, emerging evidence suggests that the repair of DNA double-strand breaks, rather than ...

Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...