Getting DNA into a living cell sounds simple, until you remember the cell’s outer membrane acts like a guarded wall. DNA strands carry a negative charge, and they do not cross that wall easily.

A fleeting DNA fold called i‑DNA can switch cancer‑related genes on and off, revealing a hidden structural weak point that ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

A team led by Professor Shoichiro Asayama at Tokyo Metropolitan University has synthesized a charge-free molecule designed to sneak plasmid DNA into living cells via hydrogen bonding, dramatically ...

Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, ...

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

How does our DNA store the massive amount of information needed to build a human being? And what happens when it's stored ...

Researchers develop synthetic markers that cross the blood-brain barrier, allowing for noninvasive monitoring of the living brain via blood tests.

Human metabolism is regulated by internal clocks, the so-called circadian rhythms. Many processes, such as sugar uptake, fat ...

What do your genes have to do with growing old? Quite a lot. But is it due to the actual DNA, or the way those genes are expressed? KPBS sci-tech reporter Thomas Fudge has more on new research that ...