DNA modifications, such as CpG epigenetic marks, have long been studied to understand their role in gene expression regulation, genomic imprinting, X chromosome inactivation, transposable element ...
RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection
Aberrant DNA methylation drives cancer development, yet current screening methods require substantial resources for targeted enrichment across multiple CpG-rich regions. Early cancer detection in cell ...
A machine learning model analyzing CpG-based DNA methylation accurately predicted the origin of many different cancer types in patients with cancers of unknown primary (CUP), according to research ...
The scientists at deCODE Genetics, a subsidiary of Amgen, sought to deepen the understanding of cis-acting influences of sequence variants on CpG methylation. In the study, the scientists were able to ...
DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...
Different neuropsychiatric and neurodevelopmental conditions, such as schizophrenia, bipolar disorder, ...
Lineage tracing is a powerful tool to study development, tissue homeostasis, aging, and disease progression. Over the past decades, lineage tracing ...
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