Lynch syndrome is an inherited condition caused by pathogenic germline variants in DNA mismatch repair (MMR) genes, predisposing carriers to a spectrum of malignancies, most notably colorectal cancer.

Early detection through screening, including AI tools, is crucial for reducing CRC incidence and mortality. CRC is increasingly affecting younger adults, with a significant rise in cases among those ...

Colorectal cancer incidence in adults under 55 has nearly doubled since the mid-1990s, and it is now the leading cancer cause of death among people ages 20–49. Etiology remains multifactorial, with ...

Colorectal cancer stands as the third leading cause of cancer-related deaths in US men and the fourth leading cause in US women, according to the American Cancer Society. This year, over 150,000 ...

Incidence and mortality are rising in cohorts born after the 1950s, with three-quarters of colorectal cancers under 50 diagnosed at advanced stage, limiting curability. Preventable mortality is ...