A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its ...
Binding of a ligand to the native three-dimensional configuration of a protein increases protein stability, with a corresponding increase in the protein’s melting temperature. This indirect ...
CETSA Is Now Being Used Routinely to Demonstrate Small Molecule’s Engagement of a Specific Target in the Cell The cellular thermal shift assay (CETSA) was first described approximately 2 years ago by ...
The search for new drugs, including those for cancer, is set to speed up thanks to a new research technique invented by scientists at the Nanyang Technological University (NTU). Named the "Cellular ...
The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...
AstraZeneca has teamed up with Pelago Bioscience to examine how drug candidates interact with protein targets. The collaboration will apply Pelago’s cellular assay technology to the screening and ...
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