Researchers mapped 442,239 single nuclei from nonfailing human hearts to chart how cardiac cells change from fetal ...

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists—so far. A new multi-chamber organoid ...

This TimeCapsule reviews the major transformations in lipid metabolism and cardiovascular disease prevention during the first quarter of the 21st century and their impact on clinical practice. From ...

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far. A new multi-chamber organoid ...

In humans, a specialized mRNA translation circuit predetermines the competence for heart formation at an early stage of embryonic development, a research team at the Center for Molecular Medicine ...

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments ...

In the left part can be seen multi-omics analysis suggested some proteins (histone / non-histone), protein lactylation, and genes change significantly at different developmental stages (1 w [week], 6 ...

Although cardiovascular diseases (CVDs) are well known throughout the world, their form and the burden they cause change as a country undergoes economic development. Developing countries begin with a ...

A crucial new mechanism that helps explain how the heart’s major blood vessels form during early development – and how disruptions to this process can lead to serious congenital heart defects – has ...

Using a combination for spatial, single-cell transcriptomics and imaging data from 36 hearts, scientists from the KTH Royal Institute of Technology and their collaborators have come up with what they ...