Beta-amyloid plaques are considered a hallmark of Alzheimer’s disease, but they’re not the sole cause of the disease and its symptoms. Alzheimer’s is a complicated disease that experts are still ...

Activating two somatostatin receptors enhances amyloid beta breakdown and improves memory in models of Alzheimer’s disease.

In an unprecedented large-scale study, researchers have mapped out the first molecular events that cause harmful protein buildups in the brain of people with Alzheimer's disease. "By measuring the ...

The newest treatment approved to fight Alzheimer’s disease is a kind of drug called an anti-amyloid. It works directly on what may cause the disease, instead of just the symptoms. Anti-amyloids are ...

Melanoma cells that spread and grow in the brain secrete amyloid beta—nearly three times as much as melanoma cells that spread to other parts of the body, a new study finds. Researchers show amyloid ...

Researchers described the structure of a special type of amyloid beta plaque protein associated with Alzheimer's disease (AD) progression. Scientists showed the small aggregates of the amyloid beta ...

Piller is an investigative journalist for Science. In November 2022, Dennis Selkoe, a Harvard professor of neurologic diseases and among the most celebrated and prolific Alzheimer’s researchers, ...

ARIA is the most common side effect of anti–amyloid-beta MAB treatment. MABs increase vascular permeability, which can result in inflammation and leakage of proteinaceous fluid and blood products, ...

More than half of 95 centenarians had a low amyloid load and 9% had no amyloid, autopsy data showed. A third of centenarians had a high amyloid load comparable to Alzheimer's disease. Five ...

Watching the Alzheimer’s research world from the outside over the past two years has felt like a car ride over an unpaved mountain road without a seatbelt. In 2021, the US Food and Drug Administration ...

Medications like lecanemab (Leqembi) and donanemab (Kisunla) target amyloid plaques in the brain that build up due to Alzheimer’s disease. They may help slow disease progression for people in the ...