Investigators have ruled out a man seen carrying backpacks in late-night surveillance video near the home of missing Arizona grandmother Nancy Guthrie.

As investigators pass the three-week mark since Nancy Guthrie was last seen by her family, the sheriff leading the search had a message of hope for the family of the 84-year-old mother of "Today" anch...

Investigators are analyzing biological evidence found at Guthrie's residence, according to the Pima County Sheriff's Department, which previously said that DNA gathered at the scene could potentially ...