Using a technique to insert fluorescently labeled genes into live mice, researchers have created a new atlas that will quite literally light the way for neuroscientists to explore the maze of ...

We describe a transgenesis platform for Drosophila melanogaster that integrates three recently developed technologies: a conditionally amplifiable bacterial artificial chromosome (BAC), recombineering ...

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and at the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington’s ...

Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (Paloneva et al., 2002), a rare, autosomal-recessive disorder characterized by bone fractures and early onset frontotemporal dementia ...

The number of plaque-associated microglia was reduced in TREM2-BAC X 5xFAD (5xFAD/TREM2) mice compared with 5xFAD mice at 7 months of age. Microglial morphology also differed between genotypes: While ...

The G72/G30 gene complex is a candidate gene for schizophrenia and bipolar disorder. However, G72 and G30 mRNAs are expressed at very low levels in human brain, with only rare splicing forms observed.

"The library of BAC vectors that we are developing will enable them to identify and access any major cell type in the brain. And the transgenic mice themselves will give neuroscientists animals in ...