Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, hips) and cornerback Deommodore Lenoir (knee) won’t play. Defensive tackle Jordan Elliott (concussion) also will be sidelined.

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the portion of Friday's practice open to the media, Purdy was seen throwing—a notable improvement after limited activity earlier in the week.